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It is well known that the islet changes of pancreas could be induced by various factors, for example, obesity, hormones, pregnancy, age, etc. For the observation of the effect of age and sex, the size of the pancreatic islets and endocrine cells composing them were calculated. As an experimental animal the albino rats of Wistar strain were used. During breeding for fifty weeks, the rats were sacrificed with the interval of ten weeks and the pancreatic tissues were fixed in Bouin’s solution and stained with hematoxylin and eosin, and aldehyde fuchsin and trichrome. The results were as follows : 1. At the age of fifty weeks of the male, the islets showed marked hypertrophy with peri-and intra-insular fibrosis. 2. The changes of the islets are found more earlier and severe in the male than in the female. 3. The frequency of appearance of pancreatic endocrine cells seemed not to change greatly during the increase of age.
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